although effective
progestational and antiandrogenic adverse effects due to. Spironolactone information from Drugs.com, includes Adult friend Spironolactone Ty the Tasmanian Tiger 2: side effects, interactions and indications. Correspondence from The New England Journal of Medicine -- Spironolactone and ACE Inhibition in Chronic
Renal Failure. The diuretic spironolactone can cause dangerous hyperkalaemia in patients who are also taking angiotensin converting enzyme (ACE) inhibitors, another drug. A pilot study had previously shown that the higher the dosage of spironolactone 
(up to 24% with 75 mg a day) the higher the risk of hyperkalaemia.2 Standard. The antiandrogen effects of spironolactone have been shown to cause feminization
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in animal studies. Two case reports did not demonstrate. Grauballe MCB, Bentzen BH, Bjrnsson M, Moe
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TEN, Bendtzen K, Stoltze K, Holmstrup P. The effect of spironolactone on experimental periodontitis. Until
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spironolactone was considered only as an antagonist at the aldosterone receptors of the epithelial cells of the kidney and was used. OBJECTIVE To assess the effect of spironolactone,
and the use of this drug as a single agent in the 